New paper (Chandra): PrEP Reinitiation as a Target for Reducing HIV Incidence
New paper led by Christina Chandra in Lancet Regional Health – Americas: PrEP Reinitiation, Uptake, and Persistence as Targets for Reducing HIV Incidence and Racial and Ethnic Inequities among Men Who Have Sex with Men in Boston, USA: A Network Modeling Study. A network model of 100,000 cisgender men in Boston was parameterized with electronic health record data from 37,722 men (2012–2023) and calibrated to local surveillance. Over 10 years, doubling reinitiation averted 15.8% of infections (1,481; number needed to treat 40), versus 10.0% for doubling uptake and 5.6% for maximizing persistence; a fivefold increase averted 32.6% at the same number needed to treat. Equity-focused reinitiation among Black and Hispanic men produced the most favorable relative disparity patterns, though inequities remained.
