New paper (Jenness): Evolving Drivers of PrEP Discontinuation among US MSM
New paper in AIDS: Evolving Drivers of Pre-Exposure Prophylaxis Discontinuation among United States Men Who Have Sex with Men, 2018–2024. We pooled seven waves of the American Men’s Internet Survey and analyzed 3,074 former PrEP users who reported reasons for stopping, estimating adjusted prevalence by year with g-computation. Altered sexual activity was the most common reason (55%), followed by side effects (31.6%) and financial or access barriers (29.4%). After adjustment, altered sexual activity rose from 46.2% in 2018 to 61.2% in 2024, while privacy and discrimination concerns doubled from 5.6% to 11.3%, the only reason with a significant linear trend. Latent class analysis identified three discontinuation profiles; being uninsured most strongly predicted financial discontinuation (aOR 4.31).
