New paper (Le Guillou): Risks and Benefits of Low-Barrier HIV PrEP Access
paper
New paper led by Adrien Le Guillou in the Journal of Infectious Diseases: Potential Risks and Benefits of Low-Barrier Access and Monitoring for HIV Preexposure Prophylaxis: A Modeling Study. A network model of HIV/STI transmission among gay, bisexual, and other men who have sex with men in Atlanta compared clinic-based PrEP against over-the-counter delivery with simplified initiation and reduced monitoring. A 50% increase in PrEP coverage averted 15.4% of HIV infections, but clinical risks rose alongside it, including renal impairment exposure and TDF/FTC resistance. Sensitivity analyses indicated that confirming HIV-negative status at initiation reduced resistance by more than 90% without reducing prevention benefits.