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New paper (Jones): HealthMindr PrEP RCT

paper
Published

August 12, 2025

New paper led by Jeb Jones in JAIDS: Randomized Controlled Trial of a HIV Prevention App to Increase Pre-exposure Prophylaxis Uptake among Gay and Bisexual Men Who Have Sex with Men in the United States: The HealthMindr PrEP Study. The trial randomized 658 gay and bisexual men who have sex with men in Ending the HIV Epidemic priority jurisdictions to the HealthMindr-PrEP app (437) or a control app (221), with follow-up over one year. Differences between arms in self-reported pre-exposure prophylaxis (PrEP) uptake were not statistically significant. Among participants with PrEP indications at baseline, the estimated rate of PrEP initiation was higher in the intervention arm, though the interval was consistent with no effect (hazard ratio 1.64, 95% CI 0.89 to 3.03); the estimate among those without indications was 1.05.

CONSORT flow diagram for the HealthMindr PrEP trial, showing allocation to the intervention and control apps and retention through 12 months of follow-up

PubMed · DOI