New paper (Onwubiko): Depression at PrEP Initiation and PrEP Care Engagement
paper
New paper led by Udodirim Onwubiko in JAIDS: Impact of Depression at HIV PrEP Initiation on Sustained PrEP Care Engagement among US Gay and Bisexual Men. The study analyzed electronic health records for 8,077 gay and bisexual men prescribed oral preexposure prophylaxis (PrEP) at three Boston clinics between January 2015 and February 2022, each followed for 18 months. Baseline depression was diagnosed in 19% of the cohort. Over follow-up, 41% had prescription gaps, 38% dropped out, and 0.4% seroconverted without a prior gap. Depression was modestly associated with higher rates of prescription gaps (adjusted hazard ratio 1.10, 95% CI 1.00-1.20) and dropping out (1.16, 95% CI 1.05-1.28) relative to men without depression.
